Unlucky assassin Ladybug is determined to do his job peacefully after one too many gigs gone off the rails. Fate, however, may have other plans, as Ladybug's latest mission puts him on a collision course with lethal adversaries from around the globe—all with connected, yet conflicting, objectives—on the world's fastest train.

When Superman and the rest of the Justice League are kidnapped, Krypto the Super-Dog must convince a rag-tag shelter pack - Ace the hound, PB the potbellied pig, Merton the turtle and Chip the squirrel - to master their own newfound powers and help him rescue the superheroes.

After his retirement is interrupted by Gorr the God Butcher, a galactic killer who seeks the extinction of the gods, Thor enlists the help of King Valkyrie, Korg, and ex-girlfriend Jane Foster, who now inexplicably wields Mjolnir as the Mighty Thor. Together, they embark upon a harrowing cosmic adventure to uncover the mystery of the God Butcher’s vengeance and stop him before it’s too late.